BBB |
blood–brain barrier |
CNS |
central nervous system |
EAE |
experimental autoimmune encephalomyelitis |
IL-1β |
interleukin 1β |
IL-6 |
interleukin 6 |
TNFα |
tumor necrosis factor |
CX3CL1 |
chemokine (C-X3- C motif) ligand 1or fractalkine |
CX3CR1 |
chemokine (C-X3-C motif) receptor 1 |
MCP-1 |
monocyte chemoattractant protein 1 |
CCL2 |
chemokine (C-C motif) ligand 2 |
MIP-1α |
macrophage inflammatory protein 1-alpha |
CCL3 |
chemokine (C-C motif) ligand 3 |
RANTES |
regulated on activation, normal T cell expressed and secreted |
CCL5 |
chemokine (C-C motif) ligand 5 |
TREM2 |
triggering receptor expressed on myeloid cells 2 |
LPS |
lipopolysaccharide |
ApoE |
apolipoprotein E |
MERTK |
Mer receptor tyrosine kinase |
MEGF10 |
multiple EGF-like-domains 10 |
BAI1 |
brain-specific angiogenesis inhibitor 1 |
GFAP |
glial fibrillary acidic protein |
EGF |
epidermal growth factor |
FGF |
fibroblast growth factor |
TGF-β |
transforming growth factor β |
ER |
estrogen receptors |
PR |
progesterone receptor |
AR |
androgen receptor |
PTMs |
post-translational modifications |
NF-κB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
MMP9 |
metalloproteinase 9 |
PGE2 |
prostaglandin E2 |
iNOS |
nitric oxide synthases |
SERMs |
selective estrogen receptor modulators |
STEAR |
selective tissue estrogenic activity regulator |