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Illustration of inflammatory pain pathways attenuated by EA in the cerebellum. We found that EA at 1 mA, 2 Hz for 20 min and TRPV1 gene deletion can diminish the expression of TRPV1, Nav1.7, Nav1.8, ASIC3, and RAGE nociceptors in the CFA-induced inflammatory pain model in CFA + EA and CFA + KO groups. Furthermore, the reductions cause decreases in the signals of pPI3K, pmTOR, pAkt, pERK, pPKCε, pPKAIIα, pNFkB, pCREB, and S100B under conditions of inflammatory hyperalgesia.
