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. 2020 May 18;11:478. doi: 10.3389/fphys.2020.00478

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Copyright © 2020 Hu and Kontrogianni-Konstantopoulos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular pathway annotation of proteins with altered expression levels in left ventricles of 1-year-old knock-in female animals. The expression levels of proteins involved in cellular metabolism (cyan) and signaling (pink) pathways are significantly altered in 1-year-old R4344Q myocardia (n = 3) compared to isogenic gender- and age-matched control animals (n = 3). The p-value for each molecular pathway is represented by the height of the respective bar after being transformed into the negative logarithmic value with the base of 2. The number of proteins whose expression levels are altered in each pathway are denoted in the relevant columns.