TABLE 1.

Altered expression levels of proteins involved in cardiac function and disease.

Gene	Protein	% Change (95% Confidence interval)	P-value	Unique peptides	Total peptides	Function or disease
CACNA1C	Calcium channel, voltage-dependent, L-type, alpha 1C subunit	−16.4(−26.1,−5.6)	0.0151	9	9	Short QT syndrome; Long QT syndrome
KCNQ1	Potassium channel, voltage-gated, subfamily Q, member 1	−19.0(−31.6,−4.2)	0.0253	1	1
ANK1	Small Ankyrin 1.5	44.0(2.0,103.3)	0.0426	1	3	Cardiac output
DDAH1	Dimethylarginine dimethylaminohydrolase 1	45.5(24.1,70.6)	0.0028	2	3
NPPA	Natriuretic polypeptide type A	−37.4(−60.1,−1.8)	0.0447	3	3
PKG1	Protein kinase, cGMP-dependent, type 1 (PKG1)	43.6(1.5,103.1)	0.0444	1	5
KCNQ1	Potassium channel, voltage-gated, subfamily Q, member 1	−19.0(−31.6,−4.2)	0.0253	1	1	Familial atrial fibrillation
NPPA	Natriuretic polypeptide type A	−37.4(−60.1,−1.8)	0.0447	3	3
FHL2	Four and a half LIM domains 2	−56.0(−79.7,−4.6)	0.0422	5	5	Relaxation of aortic ring tissue
NPPA	Natriuretic polypeptide type A	−37.4(−60.1,−1.8)	0.0447	3	3
CACNA1C	Calcium channel, voltage-dependent, L-type, alpha 1C subunit	−16.4(−26.1,−5.6)	0.0151	9	9	Supraventricular tachycardia
NPPA	Natriuretic polypeptide type A	−37.4(−60.1,−1.8)	0.0447	3	3
GUCY1A2	Guanylate cyclase 1, alpha 2	−16.2(−28.1,−2.5)	0.0317	1	1	Acute heart failure
MME	Membrane metallo endopeptidase	17.3(1.1,36.0)	0.0407	2	2
DYSF	Dysferlin	−34.2(−49.5,−14.2)	0.0118	40	42	Early onset cardiomyopathy
NPPA	Natriuretic polypeptide type A	−37.4(−60.1,−1.8)	0.0447	3	3	Mild congestive heart failure