TABLE 5.
Altered expression levels of proteins involved in metabolism.
| Gene | Protein | % Change (95% Confidence interval) | P-value | Unique peptides | Total peptides | Function |
| ABAT | 4-aminobutyrate aminotransferase | −29.9(−38.6,−19.9) | 0.0018 | 8 | 8 | Catabolism of lipids |
| ACOT7 | Acyl-CoA thioesterase 7 | 22.0(1.2,47.2) | 0.0418 | 5 | 5 | |
| DDHD2 | DDHD domain containing 2 | 30.4(0.3,69.5) | 0.0486 | 1 | 1 | |
| HEXB | Hexosaminidase B | 11.5(3.9,19.7) | 0.0129 | 3 | 3 | |
| MGLL | Monoglyceride lipase | −14.6(−27.0,−0.1) | 0.0488 | 3 | 3 | |
| SLC27A4 | Solute carrier family 27 | 19.4(0.9,41.2) | 0.0428 | 3 | 4 | |
| VLDLR | Very low density lipoprotein receptor | 7.6(1.2,14.3) | 0.0291 | 8 | 8 | |
| ABAT | 4-aminobutyrate aminotransferase | −29.9(−38.6,−19.9) | 0.0018 | 8 | 8 | Metabolism of amino acids |
| BCKDHB | Branched chain ketoacid dehydrogenase E1, beta polypeptide | −18.6(−31.3,−3.5) | 0.0284 | 5 | 5 | |
| DDAH1 | Dimethylarginine dimethylaminohydrolase 1 | 45.5(24.1,70.6) | 0.0028 | 2 | 3 | |
| DDO | D-aspartate oxidase | −55.4(−74.7,−21.4) | 0.0167 | 2 | 2 | |
| GOT2 | Glutamatic-oxaloacetic transaminase 2, mitochondrial | −16.8(−30.0,−1.2) | 0.0408 | 29 | 29 | |
| IVD | Isovaleryl coenzyme A dehydrogenase | −12.5(−20.2,−4.1) | 0.0156 | 19 | 19 | |
| MCCC2 | Methylcrotonoyl-coenzyme A carboxylase 2 | −12.2(−20.3,−3.4) | 0.0198 | 22 | 22 | |
| NPPA | Natriuretic polypeptide type A | −37.4(−60.1,−1.8) | 0.0447 | 3 | 3 | |
| PTS | 6-pyruvoyl-tetrahydropterin synthase | −13.6(−24.3,−1.4) | 0.0375 | 2 | 2 | |
| ACOT7 | Acyl-CoA thioesterase 7 | 22.0(1.2,47.2) | 0.0418 | 5 | 5 | Metabolism of coenzyme A |
| MCCC2 | Methylcrotonoyl-coenzyme A carboxylase 2 | −12.2(−20.3,−3.4) | 0.0198 | 22 | 22 | |
| SLC27A4 | Solute carrier family 27 | 19.4(0.9,41.2) | 0.0428 | 3 | 4 | |
| HEXB | Hexosaminidase B | 11.6(3.9,19.7) | 0.0129 | 3 | 3 | Metabolism of N-acetylglucosamine |
| NAGK | N-acetylglucosamine kinase | −14.7(−21.0,−7.8) | 0.0047 | 5 | 5 | |
| CST3 | Cystatin C | −32.6(−50.2,−8.7) | 0.0225 | 3 | 3 | Hydrolysis of protein fragments |
| CTSS | Cathepsin S | −16.6(−30.2,−0.4) | 0.0470 | 1 | 1 | |
| CTSZ | Cathepsin Z | 50.0(15.8,94.1) | 0.0121 | 2 | 2 | |
| FBXO6 | F-box protein 6 | −18.8(−27.6,−8.8) | 0.0075 | 2 | 2 | |
| HDAC6 | Histone deacetylase 6 | −14.0(−24.5,−2.0) | 0.0324 | 5 | 5 | |
| IDE | Insulin degrading enzyme | 6.4(1.7,11.4) | 0.0188 | 8 | 8 | |
| MME | Membrane metallo endopeptidase | 17.3(1.1.36.0) | 0.0407 | 2 | 2 | |
| TRAF3 | TNF receptor-associated factor 3 | 9.1(0.3,18.7) | 0.0451 | 1 | 1 | |
| UBE2N | Ubiquitin-conjugating enzyme E2N | −11.8(−20.0,−2.7) | 0.0236 | 7 | 7 | |
| SLC25A20 | Solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 | 16.7(9.2,24.6) | 0.0029 | 14 | 14 | Canitine acyl-carnitine translocase deficiency |
| MGLL | Monoglyceride lipase | −14.6(−27.0,−0.1) | 0.0488 | 3 | 3 | Hydrolysis of glycerol |
| OXCT1 | 3-oxoacid CoA transferase 1 | −15.1(−24.1,−5.1) | 0.0152 | 23 | 23 | Metabolism of ketone body |
| GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | −11.8(−21.3,−1.2) | 0.0371 | 22 | 22 | Production of glyceraldehyde- 3-phosphate |