TABLE 6.

Altered expression levels of proteins involved in various molecular pathways.

Gene	Protein	% Change (95% Confidence interval)	P-value	Unique peptides	Total peptides	Molecular Pathways
CYB5A	Cytochrome b5 type A (microsomal)	−39.6 (−62.2, −3.5)	0.0405	4	4	γ-linolenate biosynthesis II
SLC27A4	Solute carrier family 27 (fatty acid transporter), member 4	19.4 (0.9, 41.2)	0.0428	3	4
ACOT2	Acyl-CoA thioesterase 2	20.4 (4.3, 39.1)	0.0231	8	15	Stearate biosynthesis I
ACOT7	Acyl-CoA thioesterase 7	22.0 (1.2, 47.2)	0.0418	5	5
SLC27A4	Solute carrier family 27 (fatty acid transporter), member 4	19.4 (0.9, 41.2)	0.0428	3	4
ACOT2	Acyl-CoA thioesterase 2	20.4 (4.3, 39.1)	0.0231	8	15	Acyl-CoA hydrolysis
ACOT7	Acyl-CoA thioesterase 7	22.0 (1.2, 47.2)	0.0418	5	5
NUDT12	Nudix (nucleoside diphosphate linked moiety X)-type motif 12	66.5 (15.9, 139.1)	0.0174	4	4	NAD salvage pathway II
NMNAT3	Nicotinamide nucleotide adenylyltransferase 3	18.9 (7.1, 32.0)	0.0100	4	4	NAD salvage pathway II and III
IVD	Isovaleryl coenzyme A dehydrogenase	−12.5 (−20.2, −4.1)	0.0156	19	19	Leucine degradation I
MCCC2	Methylcrotonoyl-coenzyme A carboxylase 2	−12.2 (−20.3, −3.4)	0.0198	22	22
HSD17B10	Hydroxysteroid (17-beta) dehydrogenase 10	−10.2 (−15.3, −4.8)	0.0070	14	14	Fatty Acid β-oxidation
IVD	Isovaleryl coenzyme A dehydrogenase	−12.5 (−20.2, −4.1)	0.0156	19	19
SLC27A4	Solute carrier family 27 (fatty acid transporter), member 4	19.4 (0.9, 41.2)	0.0428	3	4
PTPN11	Protein tyrosine phosphatase, non-receptor type 11	20.8 (9.1, 33.8)	0.0067	21	21	Role of JAK2 in hormone-like cytokine signaling
SIRPA	Signal-regulatory protein alpha	17.8 (5.7, 31.3)	0.0138	2	2
NR1D1	Nuclear receptor subfamily 1, group D, member 1	42.0 (2.2, 97.3)	0.0414	2	2	Circadian rhythm signaling