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. 2020 Apr 20;105(7):2300–2310. doi: 10.1210/clinem/dgaa216

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Insulin enhances GU in human femoral BMAT. Glucose uptake (µmol/l/min) in vertebral and femoral BM in healthy control subjects (n = 9). Volume of interest (VOI) in femoral bone marrow in cross-sectional image (A) and sagittal image (B); and in vertebral bone marrow in cross-sectional image (C) and sagittal image (D). E: Regional GU (µmol/l/min) in lumbar vertebral bone marrow (Vert BM, n = 9), femoral bone marrow (Femur BM, n = 9), skeletal muscle (Muscle, n = 9), abdominal subcutaneous adipose tissue (SAT, n = 9), and visceral adipose tissue (VAT, n = 6) during fasting state and hyperinsulinemic euglycemic clamp. P-values for clamp-induced change are given as: *P < 0.05, **P < 0.01, ***P < 0.001, NS not significant P > 0.05. The lines of the boxes represent the 25^th, 50^th, and 75^th percentiles, whiskers 10^th and 90^th percentiles, and the square indicates the mean value. F: Correlation between femur BMAT GU (µmol/l/min) and M-value (µmol/min/kg) (N = 9). Values are mean + SEM.