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. 2020 Apr 30;21(9):3191. doi: 10.3390/ijms21093191

Figure 5.

Figure 5

LS iPSC-derived neurons are electrophysiologically functional. (A) Neurons derived from control (black) and patient (orange) neural stem cells were able to generate action potentials (APs) upon current injection. (B) Graph showing the injected current versus the number of APs elicited (n = 8). (C) Bar diagram of the maximal number of APs induced (n = 8, n.s.). (D) Voltage traces show that current injection (ramp from 0–300 pA) induces trains of APs; * denotes the expanded AP17. (E,F) Left: Current traces of the fast inward current peak (E) and the sustained outward current (F) activated by step depolarizations from a holding potential of −70 mV in the absence and presence of 1 mM TTX (E) or 1 mM TTX and 10 mM TEA (F); * denotes the fast inward current peak (E) and the sustained outward current (F). Right: Voltage–current plot of the inward current peak (E) and sustained outward current (F).