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. 2020 May 11;21(9):3400. doi: 10.3390/ijms21093400

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Parameters of the mitochondrial oxygen consumption rate (OCR) and residual oxygen affected by bicalutamide (Bic). Rat mesangial cells (RMCs) were untreated or treated with Bic at doses of 30 and 60 μM for 24 h. The basal respiration, maximal respiration and ATP production in cells all decreased. More residual oxygen consumption (ROX) remained at the higher dosage of Bic. (a) Time course and OCR curve plot obtained by a Seahorse analyzer. Quantification of changes in parameters induced by Bic treatment included (b) basal respiration, (c) proton leakage, (d) maximal respiration, (e) ATP production and (f) time course of residual oxygen in RMCs untreated or treated with Bic at 30 and 60 μM. Data are expressed as the mean±standard deviation (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.005 compared to untreated cells; ^# p < 0.05, ^## p < 0.01 compared to 30 μM Bic-treated cells.

Parameters of the mitochondrial oxygen consumption rate (OCR) and residual oxygen affected by bicalutamide (Bic). Rat mesangial cells (RMCs) were untreated or treated with Bic at doses of 30 and 60 μM for 24 h. The basal respiration, maximal respiration and ATP production in cells all decreased. More residual oxygen consumption (ROX) remained at the higher dosage of Bic. (a) Time course and OCR curve plot obtained by a Seahorse analyzer. Quantification of changes in parameters induced by Bic treatment included (b) basal respiration, (c) proton leakage, (d) maximal respiration, (e) ATP production and (f) time course of residual oxygen in RMCs untreated or treated with Bic at 30 and 60 μM. Data are expressed as the mean±standard deviation (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.005 compared to untreated cells; ^# p < 0.05, ^## p < 0.01 compared to 30 μM Bic-treated cells.