Table 2.

Summary of studies on capsaicin-induced desensitization of pain perception.

Study By	Study Design	Subject	Measurement	Results
Meller et al. [12].	Neonatal capsaicin treatment (50 mg/kg)	Rat	Thermal hyperalgesia in a sciatic nerve ligation model	Loss of thermal hyperalgesia
Dougherty et al. [26].	Intradermal capsaicin administraion (0.1 mL, 1% solution)	Monkey	Cutaneous mechanical and thermal stimuli by an electrode	Loss of thermal and mechanical stimuli
Baamonde et al. [25].	Intra-plantar administration of 10 μg of capsaicin	Mouse	Licking behavior following complete Freund’s adjuvant injection	Induction of long-lasting analgesia for at least 2 weeks
Jeong et al. [10].	Neonatal capsaicin treatment (50 mg/kg)	Rat	Paw-withdrawal latency to radiant infrared heat stimulation, and intake volume of capsaicin water	Desensitization to noxious heat stimuli and impaired sensing of capsaicin
Nagy et al. [30].	Neonatal capsaicin treatment (5 to 100 mg/kg)	Rat	Noxious thermal, mechanical, and chemical stimuli	Increased nociceptive threshold by higher doses of capsaicin, but the uncertain correlation with the extent of loss of primary afferent fiber