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Factors regulating PGC-1α expression and/or activity. The peroxisome-proliferator-activated receptors (PPARs) regulate, and are regulated by, PGC-1α. AMPK, P38 MAPK and SIRT1 positively regulate PGC-1α at post-transcriptional levels. GCN5, AKT, PARIS and p160MBP negatively regulate PGC-1α. PGC-1α expression and/or activity is also regulated by genes mapping to chromosome 21.
