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. 2020 Apr 29;21(9):3134. doi: 10.3390/ijms21093134

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The role of mammalian target of rapamycin complex1 (mTORC1) in regulating mitochondrial homeostasis. mTORC1 inhibits autophagy by phosphorylating the regulatory complex formed by unc-51–like kinase (ULK1) and its interacting proteins, autophagy-related protein 13 (ATG13) and focal adhesion kinase family interacting protein of 200 kDa (FIP200) (on the left). mTORC1 stimulates the mitochondrial fission by phosphorylating 4E-BPs, thus promoting translation initiation of MTFP1 (on the right). mTORC1 also represses mitophagy gene expression and regulates the expression of several mitochondrial genes (in the center).