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. 2020 Apr 27;21(9):3077. doi: 10.3390/ijms21093077

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary of Drug-LGIR assay in monkeys. (A–F) The results of Drug-LGIR assay with dexamethasone (Dexa), prednisolone (PSL), betamethasone (Beta), hydrocortisone (Hydro), triamcinolone (TA), and cyclosporine A (CsA) in PBMC from six monkeys: HM-5 (A), HM-6 (B), HM-7 (C), and HM-8 (D) that were not transplanted (n = 4) and HM-1 (E) and HM-2 (F) that showed RPE-rejection after transplantation (n = 2). The rate of proliferative immune cells indicated by expression of Ki-67 by FACS are shown in bar graphs to evaluate the suppressive effect of each drug. Red dotted-lines indicate the baseline (Control = 1.0, PBMC + iPS-RPE cells without drug). nt: not tested.