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. 2020 Apr 27;21(9):3077. doi: 10.3390/ijms21093077

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Results of iPSC-RPE transplantation while using cyclosporine A. (A) The fundus photograph of monkey HM-5 at 24 weeks after surgery, who was subjected to human iPSC-RPE transplantation with administration of cyclosporine A before the transplantation. Arrows show the transplanted sites. (B) Fluorescein angiography (FA) at late phase showed no hyperfluorescence around the grafts (arrows). No FA leakage was observed during the 24-week evaluation period. (C) Optical coherence tomography (OCT) showed the presence of cell aggregates of graft cells (arrow) in the subretinal space. (D) The graft cells (arrow) but not inflammatory cells were observed in the subretinal space by H&E staining. Scale bar: 50 μm. (E–F) IHC with CD3 (green) and DAPI (blue). RPE grafts were detected in the subretinal space (arrows). CD3⁺ T cells were not observed in the retina (F). Scale bars: 20 μm.