Figure 1.

Effect of BME (50 mg/kg) on spatial working memory in adolescent mice after 7- and 28-day treatment. Spatial working memory was elucidated by the modified Y-maze test. Sample and test trials were conducted for 5 min with a 30-min interval (A). In the sample trial, each mouse was individually placed in the maze with one of the three arms closed. The arm that was closed in the sample trial was defined as the new arm in the test trial. Summarized data was obtained on days 7 and 28 after the BME treatment (B). Results are expressed as percent time animals spent exploring the new arm in the test trial. Each data column represents the mean ± SEM (n = 10–11). * p < 0.05 vs. the control group.