Table 1.

BME treatment-induced changes in the expression levels of genes involved in neurogenesis-related signaling pathways in the hippocampus. The down-regulation of genes is indicated by the values in brackets. The function of each gene was identified by Genecards (https://www.genecards.org) and/or Mouse Genome Databases (http://www.informatics.jax.org).

Signaling Pathway	Gene Products	Gene Symbol	Fold Change	p-Value	Neurogenesis-Related Function Citation
Neurotrophin signaling pathway	NT3	NTRK2 (TrKB)	1.325	< 0.0001	Receptor tyrosine kinase is involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, alternatively, can also bind NTF3/neurotrophin-3, which is less efficient in activating the receptor but regulates neuron survival.
		NTRK3 (TrKC)	1.501	< 0.0001	NTF3/neurotrophin-3, NTRK3, autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, which control cell survival and differentiation.
PI3K-Akt	PP2A	Ppp2r3d	(1.342)	0.005	Cell proliferation
		Ppp2r1a	(1.371)	0.012	Cell death, cell differentiation, cellular component organization
		Ppp2r5a	(1.228)	0.009	Lipid metabolic process, protein metabolic process, response to stimulus, signaling
		Ppp2r5b	(1.354)	0.008	Cell differentiation, cellular component organization, nucleic-acid-templated transcription, protein metabolic process response to stimulus, signaling, system development
	PI3K class IA	Pik3ca	1.342	0.009	Cell death, cell population proliferation, establishment of localization, homeostatic process, lipid metabolic process, protein metabolic process, response to stimulus signaling, system development
		Pik3cb	1.351	0.001	Cell death, establishment of localization, homeostatic process, immune system process, lipid metabolic process, response to stimulus, signaling, system development
		Pik3r1	1.367	0.008	Cell death, cell differentiation, cell population proliferation, cellular component organization, establishment of localization, homeostatic process, immune system process, lipid metabolic process, nucleic-acid-templated transcription, protein metabolic process, response to stimulus, signaling, system development
		Pik3cg	1.968	0.000	Cell death, establishment of localization, homeostatic process, immune system process, lipid metabolic process, protein metabolic process, response to stimulus signaling, system development
	AKT	Akt1	(1.282)	0.035	Cell death, cell differentiation, cell population proliferation, cellular component organization, establishment of localization, homeostatic process immune system process, lipid metabolic process, nucleic-acid-templated transcription, protein metabolic process response to stimulus, signaling, system development
		Akt3	1.615	< 0.0001	Cell population proliferation, cellular component organization, establishment of localization, homeostatic process
	GF	HgfP	2.213	0.035	Cell death, cell differentiation, cell population proliferation, cellular component organization
	PKC	PrkcaR	1.546	< 0.0001	Cell death, cell differentiation, cell population proliferation, cellular component organization, establishment of localization, homeostatic process, immune system process
		Prkcb	1.249	0.000	Cell death, cellular component organization, establishment of localization, homeostatic process, immune system process, nucleic-acid-templated transcription protein metabolic process, response to stimulus signaling system development
CREB	pCREB	Creb1	1.337	0.016	Cell differentiation, cellular component organization, signaling, system development
		Atf2	1.323	0.003	Cell death, cell differentiation, cell population proliferation, cellular component organization, establishment of localization
Cholinergic receptor	ChAT	ChatE	3.970	0.005	Cell differentiation, cellular component organization, signaling, system development
	M2	Chrm2	1.582	0.003	Establishment of localization, response to stimulus, signaling
	M5	Chrm5	2.592	0.000	Establishment of localization, lipid metabolic process, response to stimulus, signaling