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. 2020 May 25;17:165. doi: 10.1186/s12974-020-01830-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Effect of STING on SAH-induced neuroinflammation. a-f Representative western blotting images and quantitative analyses of iNOS, cleaved IL-1β, NLRP3, ASC, and caspase-1 p20 expression at 24 h after SAH. g Relative mRNA level of M1 microglia markers genes (CD16, iNOS, IL-1β, IL-6, TNF-α, and MCP-1). h Representative microphotographs demonstrated the morphological changes in microglia (Iba-1, green) and CD16 positive cells. Resting microglia are characterized by small soma, long protrusions, and rod-shaped nuclei (while arrows), while activated microglia are characterized by large soma, short protrusions, and amoeboid morphology (red arrows). i, j The quantitative analysis of morphological activated microglia and CD16-positive microglia. k, l Representative microphotographs and quantitative analysis of iNOS-positive cells (red). m-o Representative microphotographs and quantitative analysis of caspase-1-positive cells (red) and IL-1β-positive cell (green). n = 6 for each group. Data were represented as mean ± SD. *P < 0.05 versus sham group. #P < 0.05 versus SAH + vehicle group