Table 2.

Association between cortisol metabolism, childhood trauma and cognitive function.

	5β reductases (n = 114)	5α Reductases (n = 114)
Physical abuse	r = 0.26 p = 0.005	r = 0.15 p = 0.10
Sexual abuse	r = 0.20 p = 0.035	r=0.12 p=0.22
Emotional abuse	r = 0.17 p = 0.07	r=0.12 p=0.19
Physical neglect	r = 0.07 p = 0.49	r = 0.06 p = 0.57
Emotional neglect	r = 0.12 p = 0.20	r = 0.18 p = 0.06
Memory	r = 0.05 p = 0.60	r = −0.02 p = 0.80
Working memory	r = −0.15 p = 0.11	r = −0.23 p = 0.01
Executive function	r = −0.15 p = 0.11	r = −0.19 p = 0.05
Verbal abilities	r = 0.04 p = 0.70	r = −0.10 p = 0.30
Perception and visuo-spatial abilities	r = −0.06 p = 0.53	r = −0.09 p = 0.34
GAF	r = −0.17 p = 0.08	r = −0.22 p = 0.02
PANSS	r = 0.14 p = 0.15	r = 0.23 p = 0.01

Spearman’s correlation; aTHF, allo-tetrahydrocortisol; THF, tetrahydrocortisol; THE, tetrahydrocortisone; UFF, urinary free cortisol; UFE, urinary free cortisone; 5α- and 5β reductases were calculated with aTHF/UFF and THF/UFF indexes respectively.