Table 1.
Genetic evidence for inflammasome involvement in immune-related skin diseases.
| Gene | Variants | Sample size (case/control) | OR | Population | Disease subtype | References |
|---|---|---|---|---|---|---|
| SLE | ||||||
| TLR7 | rs179008-T | 282/309 | 1.74 | European | SLE | (46) |
| NLRP1 | rs2670660-G | 144/158 | 2.06 | Brazilian | SLE | (47) |
| TLR9 | rs187084-? | 285/305 | 2.23 | Chinese Taiwan | SLE | (48) |
| P2X7R | rs1718119 -G | 535/532 | 0.64 | Chinese | LN | (49) |
| TLR9 | rs35214-T | 430/424 | 1.43 | Chinese | SLE | (50) |
| IL-1b | rs1143629-G | 90/144 | 1.95 | Brazilian | Juvenile-onset SLE | (51) |
| Psoriasis | ||||||
| NLRP3 | rs10733113-G | 741/1002 | 2.06 | Chinese | Psoriasis | (52) |
| CARD8 | rs2043211-? | 741/1002 | 1.3 | Chinese | Psoriasis | (52) |
| NLRP1 | rs8079034-C | 773/802 | 1.45 | Swedish | Psoriasis | (53) |
| AIM2 | rs2276405-A | 11245/11177 | 0.83 | Chinese | Psoriasis | (54) |
| Vitiligo | ||||||
| NALP1 | rs6502867-A | 114 families | 2.08 | USA and UK | Vitiligo/Autoimmune disease | (55) |
| NALP1 | rs1008588-A | 26/61 | na | Jordanian | Vitiligo | (56) |
| NALP1 | Nine mutation block | 114 families | 3.7 | USA and UK | Vitiligo/Autoimmune disease | (57) |
| AD | ||||||
| NOD1 | Insertion/deletion-32,656 | 600 asthma/1,194 control | 6.3 | German | Atopic and non-atopic diseases | (58) |
| CARD15 | R702W | 392/297 | 1.98 | German | AD | (59) |
| NALP12 | In9 | 392/297 | 1.28 | German | AD | (59) |
| NLRP1 | rs12150220-? | 1260/732 | 0.54 | Swedish | AD | (60) |
SLE, systemic lupus erythematosus; AD, atopic dermatitis; LN, lupus nephritis; OR, odd ratio.