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. 2020 May 14;8:241. doi: 10.3389/fped.2020.00241

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Copyright © 2020 Harer and Chock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic window created by monitoring renal tissue oxygenation. This figure shows the theoretical timeline of changes in a patient with acute kidney injury. Initially tissue oxygenation changes occur followed by a later decrease in urine output and an increase in serum creatinine. Changes in urine output and serum creatinine may signal permanent tissue injury, while changes in tissue oxygenation may reflect an earlier time period when renal ischemia is still reversible and responsive to fluid management, transfusions, inotropic support, or medication administration that may resolve ongoing injury.