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Hepatocytes are important efferocytes. Comprising up to 80% of the liver mass, hepatocytes engulf apoptotic and necrotic cells via the asialoglycoprotein receptor (ASGR1) (3), and rapidly degrade them. This process may supply the liver with nutrients while maintaining homeostasis by eliminating pro-inflammatory cell debris. CIC structures can also lead to failure of cytokinesis (19) and this can impact hepatocyte ploidy.
