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. 2020 May 14;14:441. doi: 10.3389/fnins.2020.00441

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Copyright © 2020 Dionisio-Santos, Behrouzi, Olschowka and O’Banion.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arginase-1 expression in the subiculum after IL-4 injection. (A) Representative images of subiculum of 16-month-old 3xTg AD and non-transgenic mice stained with arginase-1 and P2RY12 to specifically label microglia after saline or IL-4 injection (scale bar, 25 μm). (B) Representative flow cytometry plots proportion of CD45^hi (monocytes) and CD45^mid (microglia) cells in the CD11b positive population isolated from the hippocampus after saline or IL-4 injection. (C,D) Numerical data represented as% of CD45^mid (C) and CD45^hi (D) cells in the CD11b positive population ± SEM; n = 7–8 per group.