TABLE 3.
GO and KEGG enrichment analysis of 21 hub genes.
| Category | Pathway ID | Pathway term | Ajusted p-value | Gene count | Genes |
| KEGG | mmu04610 | Complement and coagulation cascades | 0.001254913 | 5 | Fgg, Fga, Serpine1, Pros1, F2r |
| mmu05166 | HTLV-I infection | 0.007973337 | 6 | Egr1, Fos, Pdgfb, Myc, Fosl1, Tgfb1 | |
| mmu05200 | Pathways in cancer | 0.027346417 | 6 | Fos, Ptgs2, Pdgfb, Myc, Tgfb1, F2r | |
| mmu04668 | TNF signaling pathway | 0.028768196 | 4 | Fos, Ptgs2, Edn1, Mmp3 | |
| BP | GO:0008284 | Positive regulation of cell proliferation | 5.84E−08 | 11 | Casr, Ptgs2, Pdgfb, Ctgf, Agt, Clu, Edn1, Myc, Tgfb1, F2r, Timp1 |
| GO:0045907 | Positive regulation of vasoconstriction | 4.39E−07 | 6 | Fgg, Casr, Ptgs2, Fga, Pdgfb, F2r | |
| GO:0048146 | Positive regulation of fibroblast proliferation | 1.81E−04 | 5 | Pdgfb, Agt, Serpine1, Myc, Tgfb1 | |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | 3.02E−04 | 6 | Fgg, Fga, Pdgfb, Ctgf, Tgfb1, F2r | |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | 2.50E−04 | 5 | Egr1, Ptgs2, Pdgfb, Edn1, Myc | |
| GO:0007596 | Blood coagulation | 2.54E−04 | 5 | Fgg, Fga, Pdgfb, Pros1, F2r | |
| CC | GO:0005615 | Extracellular space | 1.14E−08 | 14 | Fgg, Fga, Pdgfb, Ctgf, Agt, Edn1, Clu, Serpine1, Anxa1, Mmp3, Qsox1, Pros1, Tgfb1, Timp1 |
| GO:0005576 | Extracellular region | 6.52E−07 | 13 | Fgg, Fga, Pdgfb, Ctgf, Clu, Edn1, Serpine1, Anxa1, Mmp3, Qsox1, Pros1, Tgfb1, Timp1 | |
| GO:0072562 | Blood microparticle | 5.25E−06 | 6 | Fgg, Fga, Agt, Clu, Pros1, Tgfb1 | |
| GO:0009986 | Cell surface | 3.75E−05 | 8 | Fgg, Casr, Fga, Pdgfb, Clu, Anxa1, Tgfb1, F2r | |
| GO:0031012 | Extracellular matrix | 1.57E−04 | 6 | Pdgfb, Clu, Serpine1, Mmp3, Tgfb1, Timp1 | |
| GO:0043234 | Protein complex | 0.004754681 | 6 | Ptgs2, Clu, Anxa1, Mmp3, Myc, Pros1 | |
| MF | GO:0005102 | Receptor binding | 0.008833709 | 6 | Fgg, Fga, Pdgfb, Edn1, Serpine1, F2r |
| GO:0008083 | Growth factor activity | 0.030454845 | 4 | Pdgfb, Ctgf, Tgfb1, Timp1 | |
| GO:0030674 | protein binding, bridging | 0.075352205 | 3 | Fgg, Fga, Anxa1 | |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | 0.068271512 | 3 | Egr1, Fos, Myc |
KEGG Kyoto Encyclopedia of Genes and Genomes, BP biological process, CC cellular component, MF molecular function. 21 hub genes: Timp1, Pdgfb, Edn1, Anxa1, Casr, F2r, Fos, Tgfb1, Pros1, Fgg, Fga, Clu, Egr1, Qsox1, Agt, Serpine1, Ptgs2, Myc, Ctgf, Mmp3, Fosl1.