The correlation between CPB time and mtDNA (A,
n=50), syndecan-1 (C, n=44), WBC (E-F, n=44), and IL-6 (G-H, n=44). The correlation analysis was performed at 4–8 hours (A, C, E and G) and 24 hours (F and H) after cardiac surgery. Spearman’s rank correlation coefficient and p values are indicated. The comparisons of mtDNA (B) and syndecan-1 (D) levels between groups of patients with shorter (grey-shaded circles) and longer (gray-shaded quadrants) CPB time. The statistical significance was calculated using repeated measures two-way ANOVA with Sidak’s multiple comparisons test. P values are indicated.