Table 1.
Stepwise regression analysis of the association of LILRB binding and individual HLA alleles with psoriasis in the WTCCC and GAIN cohorts
| WTCCC (Discovery Cohort) 2,178 cases, 5,175 controls |
GAIN (Replication Cohort) 1,368 cases, 1,348 controls |
||||
|---|---|---|---|---|---|
| Variable | p-value | OR (95% CI) | Variable | p-value | OR (95% CI) |
| C0602 | 3.32E-26 | 4.20 (3.22-5.47) | C0602 | 5.27E-35 | 4.41 (3.49-5.58) |
| A0201 | 1.83E-13 | 1.70 (1.47-1.95) | DQB0604 | 2.65E-06 | 0.37 (0.25-0.56) |
| A0101 | 4.64E-08 | 1.62 (1.36-1.92) | B5001 | 2.24E-03 | 0.43 (0.25-0.74) |
| B3801 | 2.78E-02 | 1.82 (1.07-3.11) | B3801 | 3.37E-04 | 2.20 (1.43-3.39) |
| B5501 | 5.41E-05 | 1.93 (1.40-2.65) | A0201 | 1.32E-03 | 1.34 (1.12-1.61) |
| LILRB2-B | 2.33E-04 | 0.44 (0.28-0.68) | B3901 | 3.17E-03 | 2.08 (1.28-3.37) |
| DQB0604 | 1.30E-02 | 0.64 (0.45-0.91) | DRB0801 | 6.81E-03 | 0.56 (0.37-0.85) |
| A1101 | 1.64E-02 | 1.31 (1.05-1.62) | B5501 | 3.47E-03 | 1.91 (1.24-2.95) |
| C1203 | 2.66E-02 | 1.54 (1.05-2.26) | B0801 | 2.10E-03 | 1.45 (1.14-1.83) |
| B1302 | 6.15E-04 | 1.74 (1.27-2.38) | LILRB2-B | 3.43E-03 | 0.50 (0.32-0.80) |
| B5701 | 1.41E-02 | 1.49 (1.08-2.04) | |||
| B4001 | 2.69E-02 | 0.75 (0.58-0.97) | |||
| DQA0501 | 1.88E-03 | 0.77 (0.65-0.91) | |||
| B0801 | 7.66E-03 | 1.36 (1.08-1.70) | |||
| B4403 | 4.09E-02 | 0.77 (0.59-0.99) | |||
Abbreviations: GWAS, Genome Wide Association Studies; WTCCC, Wellcome Trust Case-Control Consortium.