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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Invest Dermatol. 2019 Dec 24;140(6):1292–1295.e3. doi: 10.1016/j.jid.2019.12.006

Table 1.

Stepwise regression analysis of the association of LILRB binding and individual HLA alleles with psoriasis in the WTCCC and GAIN cohorts

WTCCC (Discovery Cohort)
2,178 cases, 5,175 controls
GAIN (Replication Cohort)
1,368 cases, 1,348 controls
Variable p-value OR (95% CI) Variable p-value OR (95% CI)
C0602 3.32E-26 4.20 (3.22-5.47) C0602 5.27E-35 4.41 (3.49-5.58)
A0201 1.83E-13 1.70 (1.47-1.95) DQB0604 2.65E-06 0.37 (0.25-0.56)
A0101 4.64E-08 1.62 (1.36-1.92) B5001 2.24E-03 0.43 (0.25-0.74)
B3801 2.78E-02 1.82 (1.07-3.11) B3801 3.37E-04 2.20 (1.43-3.39)
B5501 5.41E-05 1.93 (1.40-2.65) A0201 1.32E-03 1.34 (1.12-1.61)
LILRB2-B 2.33E-04 0.44 (0.28-0.68) B3901 3.17E-03 2.08 (1.28-3.37)
DQB0604 1.30E-02 0.64 (0.45-0.91) DRB0801 6.81E-03 0.56 (0.37-0.85)
A1101 1.64E-02 1.31 (1.05-1.62) B5501 3.47E-03 1.91 (1.24-2.95)
C1203 2.66E-02 1.54 (1.05-2.26) B0801 2.10E-03 1.45 (1.14-1.83)
B1302 6.15E-04 1.74 (1.27-2.38) LILRB2-B 3.43E-03 0.50 (0.32-0.80)
B5701 1.41E-02 1.49 (1.08-2.04)
B4001 2.69E-02 0.75 (0.58-0.97)
DQA0501 1.88E-03 0.77 (0.65-0.91)
B0801 7.66E-03 1.36 (1.08-1.70)
B4403 4.09E-02 0.77 (0.59-0.99)

Abbreviations: GWAS, Genome Wide Association Studies; WTCCC, Wellcome Trust Case-Control Consortium.