Table 2.
Stepwise regression and multivariate association analysis of LILRB binding and individual HLA alleles with psoriasis in the combined WTCCC and GAIN cohorts. All variables from the stepwise analysis were included in the multivariate analysis.
| Stepwise Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| Variable | p-value | OR (95% CI) | p-value | OR (95% CI) |
| C0602 | 1.71E-123 | 5.29 (4.61-6.08) | 1.33E-123 | 5.30 (4.62-6.09) |
| B5001 | 1.71E-06 | 0.45 (0.33-0.62) | 1.83E-06 | 0.45 (0.33-0.63) |
| A0201 | 2.51E-15 | 1.57 (1.40-1.75) | 2.32E-15 | 1.57 (1.40-1.75) |
| A0101 | 3.68E-07 | 1.43 (1.24-1.63) | 4.45E-07 | 1.42 (1.24-1.63) |
| DQB0604 | 5.53E-06 | 0.53 (0.40-0.70) | 4.94E-06 | 0.53 (0.40-0.69) |
| B5501 | 2.39E-06 | 1.84 (1.43-2.37) | 2.57E-06 | 1.84 (1.43-2.37) |
| LILRB2-B | 2.20E-09 | 0.41 (0.30-0.55) | 2.34E-09 | 0.41 (0.30-0.55) |
| B4001 | 3.58E-03 | 0.75 (0.62-0.91) | 3.53E-03 | 0.75 (0.62-0.91) |
| B4403 | 1.81E-03 | 0.73 (0.60-0.89) | 1.83E-03 | 0.73 (0.60-0.89) |
| C1203 | 4.29E-07 | 1.72 (1.40-2.13) | 3.59E-07 | 1.73 (1.40-2.14) |
| B0801 | 5.40E-05 | 1.75 (1.34-2.30) | 6.54E-05 | 1.74 (1.33-2.29) |
| DQA0501 | 1.35E-02 | 0.85 (0.75-0.97) | 1.44E-02 | 0.85 (0.75-0.97) |
| A1101 | 3.61E-02 | 1.20 (1.01-1.43) | 3.87E-02 | 1.20 (1.01-1.43) |
| C0701 | 3.09E-02 | 0.76 (0.60-0.98) | 3.42E-02 | 0.77 (0.60-0.98) |
| DRB0801 | 4.76E-02 | 0.75 (0.56-1.00) | 5.47E-02 | 0.75 (0.56-1.01) |
Abbreviations: GWAS, Genome Wide Association Studies; WTCCC, Wellcome Trust Case-Control Consortium.