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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Invest Dermatol. 2019 Dec 26;140(6):1244–1252.e4. doi: 10.1016/j.jid.2019.10.022

Figure 4. KLK7 is required for the development of AD-associated itch.

Figure 4.

a. Spontaneous scratching after MC903 nape treatment in control and Klk7−/− mice; n > 8 per group. b-c. b. Representative immunofluorescence images and c. quantification of phosphorylated ERK (pERK) staining in DRGs innervating MC903-treated nape skin of control and Klk7−/− mice; n = 3 mice per group. d-e. d. Representative immunofluorescence images and e. quantification of c-Fos staining in thoracic spinal cords of MC903-treated control and Klk7−/− mice on day 6 of treatment; n = 3 mice per group. Error bars represent SEM. * p<0.05. *** p<0.001. The scale bars represent 200 μm.