Table 2.
Discriminators of spontaneous ICHs with regard to probable/definite CAA diagnosis
| Probable/definite | Non-probable | St/Chi2 | multivariate logistic regression | ||
|---|---|---|---|---|---|
| CAA | CAA | p | p | OR (95% CI) | |
| Patient number | 16 | 152 | – | – | |
| Age at eventa(y) | 75.9 ± 2.3 | 65.6 ± 1.1 | 0.002 | 0.012 | 1.08 (1.02–1.15) |
| Sex (male/female) (%) | 37.5 | 64.5 | 0.035 | > 0.05 | – |
| Prior ischemic stroke (%) | 18.8 | 10.7 | > 0.05 | – | – |
| Prior intracranial hemorrhagea(%) | 31.3 | 6.8 | 0.008 | 0.005 | 8.53 (1.94–37.58) |
| Prior TIA (TFNE) (%) | 31.3 | 7.4 | 0.010 | > 0.05 | – |
| Prior loss of consciousness (%) | 18.8 | 6.0 | > 0.05 | – | – |
| Family history for any stroke | 42.9 | 29.1 | > 0.05 | – | – |
| Anticoagulant use (%) | 18.8 | 12.8 | > 0.05 | – | – |
| INR > 1.4 (%) | 20.0 | 10.4 | > 0.05 | – | – |
| Antiplatelet usea(%) | 56.3 | 25.2 | 0.009 | 0.042 | 3.45 (1.05–11.38) |
| Combined antithrombotic use (%) | 6.4 | 4.1 | > 0.05 | – | – |
| Hypertensive excess (%) | 46.7 | 64.2 | > 0.05 | – | – |
| Chronic hypertension (%) | 93.8 | 88.8 | > 0.05 | – | – |
| Case fatality (1-month) (%) | 31.3 | 28.9 | > 0.05 | – | – |
St/Chi2, Student t test (for Age at event) or Chi2 test (for other variables); CI confidence interval, ICH intracerebral hemorrhage, INR international normalized ratio, OR odds ratio, TIA transient ischemic attack, TFNE transient focal neurological episode, y year (mean ± SEM)
aIndicates significant predictors in multivariate analyses
Bold font: indicates variables with significant difference in univariate analyses