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. 2020 May 26;6:32. doi: 10.1038/s41421-020-0161-3

Fig. 1. ATG/Atg proteins control dynamic membrane events during autophagosome biogenesis.

Fig. 1

a Autophagosome formation can be dissected into five different steps: initiation, nucleation, membrane expansion, closure, and fusion. b, c The intracellular distribution of ATG/Atg proteins under starvation-induced autophagy in mammalian (b)32,3436,48,56,58,97,127,161,172 and yeast cells (c)33,46,47,55,126,130,154,155. Their localizations are categorized into five groups: -, not detectable; -/+, transient; +, weakly detectable; ++, easily detectable; +++, clearly detectable. Note that ATG/Atg proteins show punctate structures on the ER-related membranes rather than a typical ER-like pattern. ERES ER exit sites, ERGIC ER-Golgi intermediate compartment.