Table 6,
online: Characteristics of unmatched infants
| n (column %) or mean (standard deviation)a | Prolonged antibiotics n=797 | No prolonged antibiotics n=648 | p-valueb |
|---|---|---|---|
| Maternal education | 0.001 | ||
| < High School degree | 164 (22.8) | 101 (17.6) | |
| High School degree | 193 (26.8) | 205 (35.7) | |
| > High School degree | 363 (50.4) | 269 (46.8) | |
| Unknown/missing | 77 | 73 | |
| Maternal medical insurance | <0.001 | ||
| Private | 360 (46.9) | 220 (34.1) | |
| Public/self-pay/other | 408 (53.1) | 425 (65.9) | |
| Unknown/missing | 29 | 3 | |
| Maternal race/ethnicity | <0.001 | ||
| Black, non-Hispanic | 326 (41.0) | 233 (36.8) | |
| White, non-Hispanic | 296 (37.2) | 306 (48.3) | |
| Hispanic | 109 (13.7) | 87 (13.7) | |
| Other | 64 (8.1) | 8 (1.3) | |
| Unknown/missing | 2 | 14 | |
| Maternal hypertension | 98 (12.4) | 221 (34.3) | <0.001 |
| Antepartum hemorrhage | 149 (18.7) | 166 (25.7) | 0.001 |
| Maternal clinical chorioamnionitis | 402 (50.9) | 7 (1.1) | <0.001 |
| Maternal antibiotics during delivery admission | 651 (84.0) | 430 (67.0) | <0.001 |
| Unknown/missing | 22 | 6 | |
| Antenatal steroids | 684 (86.9) | 602 (93.8) | <0.001 |
| Unknown/missing | 10 | 6 | |
| Cesarean section | 420 (52.8) | 513 (79.2) | <0.001 |
| Membrane rupture | <0.001 | ||
| >18 hours | 374 (47.6) | 54 (8.5) | |
| ≤ 18 hours | 412 (52.4) | 583 (91.5) | |
| Unknown/missing | 11 | 11 | |
| GA weeks, mean (SD) | 24.3 (1.1) | 25.3 (0.8) | <0.001 |
| By GA week | <0.001 | ||
| 22 | 25 (3.1) | 4 (0.6) | |
| 23 | 174 (21.8) | 11 (1.7) | |
| 24 | 262 (32.9) | 96 (14.8) | |
| 25 | 201 (25.2) | 230 (35.5) | |
| 26 | 135 (16.9) | 307 (47.4) | |
| BW grams, mean (SD) | 673 (130) | 785 (130) | <0.001 |
| Male | 414 (52.0) | 285 (44.2) | 0.003 |
| Endotracheal intubation at birth | 731 (91.8) | 414 (64.0) | <0.001 |
| Infant temperature within 60 minutes of birth | <0.001 | ||
| ≥ 96.5 F | 495 (68.1) | 525 (84.8) | |
| < 96.5 F | 232 (31.9) | 94 (15.2) | |
| Unknown/missing | 70 | 29 | |
| Highest respiratory support at 24 hours | <0.001 | ||
| High-frequency ventilation | 385 (48.6) | 1 (0.2) | |
| Conventional ventilation | 338 (42.7) | 276 (42.9) | |
| NIMV | 17 (2.1) | 55 (8.5) | |
| CPAP | 38 (4.8) | 282 (43.8) | |
| Other/no support | 14 (1.8) | 30 (4.7) | |
| Severe IVH diagnosed within 7 days | <0.001 | ||
| Yes | 114 (14.4) | 4 (0.6) | |
| No | 679 (85.6) | 637 (99.4) | |
| No sonogram/missing | 4 | 7 | |
| Enteral feeds started within 3 days | 147 (18.5) | 454 (70.4) | <0.001 |
BW, birth weight; CPAP, continuous positive airway pressure; EOS, early-onset sepsis; GA, gestational age; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; NIMV, non-invasive intermittent mandatory ventilation; SIP, spontaneous intestinal perforation.
The number of infants with unknown/missing information is shown for characteristics with information missing for ≥1% of infants. Otherwise, information was missing for: maternal hypertension, 7; antepartum hemorrhage, 4; maternal clinical chorioamnionitis, 12; cesarean section, 1; male sex, 4; endotracheal intubation, 2; highest respiratory support at 24 h, 9; enteral feeds within 3 days, 4 infants.
p-value by chi-square test (categorical variables) or T test (continuous variables).