Table 2.
Cost inputs
| Variable | Base-case value | Distribution | Lower limit | Upper limit | Source |
|---|---|---|---|---|---|
| Cost of interventions | |||||
| Unit cost of operating theatre per min (£) | 20.00 | Gamma | 8.80 | 28.70 | NHS [25, 27] |
| Unit cost of postoperative hospital stay in the ICU (£) | 1449.40 | Gamma | 1087.00 | 1811.70 | NHS reference cost 2017/2018 [28] |
| Unit cost of postoperative hospital stay in cardiac the ward (£) | 305.00 | Gamma | 228.80 | 381.30 | NHS reference cost 2017/2018 [28] |
| Cost of CytoSorb [materials and labour costs] (£) | 1500.00 | Fixed | NA | NA | Cytosorbents |
| Pre-CABG | |||||
| Unit cost of bed days while waiting for physiologic clearance of ticagrelor (£) | 305.00 | Gamma | 228.80 | 381.30 | NHS reference cost 2017/2018 [28] |
| Average number of hospital bed days while waiting for physiologic clearance of ticagrelor | 5.00 | Gamma | 3.00 | 7.00 | NHS Digital 2017/2018 and Sousa-Uva et al., 2014 [14] |
| Patients who will be discharged home while waiting for physiologic clearance of ticagrelor (%) | 0.00 | Fixed | NA | NA | Assumption |
| Cost of cangrelor and tirofiban (£) | 205.00 | Gamma | 153.75 | 256.25 | British National Formulary [29] |
| Cost of LMWH (£) | 30.30 | Gamma | 22.70 | 37.84 | British National Formulary [29] |
| Cost of blood clotting test (£) | 3.60 | Gamma | 2.72 | 4.53 | Inflated to 2018 [30] |
| Cost of bleeding | |||||
| Transfusion of RBCs [unit] (£) | 129.00 | Gamma | 96.70 | 161.20 | NHS Blood and Transplant |
| Transfusion of platelets [unit] (£) | 185.90 | Gamma | 139.40 | 232.30 | NHS Blood and Transplant |
| Cost of administering blood per unit (£) | 50.70 | Gamma | 38.00 | 63.40 | Stokes, 2018, inflated to 2018 [38] |
| Cost of administering platelets per unit (£) | 60.00 | Gamma | 45.00 | 75.00 | Stokes, 2018, inflated to 2018 [38] |
| Unit cost of re-thoracotomy (£) | 4800.00 | Gamma | 2100.00 | 6888.00 | Assumed to require 4 h of theatre time |
| Unit cost of treatment with desmopressin (£) | 13.16 | Fixed | NA | NA | British National Formulary [29] |
| Cost of health states | |||||
| Annual cost of post-surgery health states (£) | 2010.20 | Gamma | 1959.00 | 2061.50 | Walker et al., 2016, inflated to 2018 [31] |
CABG coronary artery bypass graft, ICU intensive care unit, LMWH low-molecular-weight heparin, NA not applicable, RBCs red blood cells