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. 2020 May 19;11:775. doi: 10.3389/fimmu.2020.00775

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Copyright © 2020 Murata and Hayashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The antibody-mediated inhibition of CD4⁺ or CD8⁺ T_RM cell formation in healed ears does not suppress the local skin memory response. (A) BALB/c mice were sensitized on back skin and anti-CD4 (GK1.5) or CD8α (53–6.7) mAbs were injected on the indicated days in order to inhibit the accumulation of effector CD4⁺ or CD8⁺ T cells in inflamed ear skin during the 1^st contact hypersensitivity. Phosphate-buffered saline was injected as a control. (B) Ear swelling upon sensitization + the 1^st challenge and re-challenge (n = 6–7 each group). (C) The numbers of CD3ε⁺, CD4⁺, and CD8αβ⁺ cells along the cartilage in ear skin sections on day 35 as assessed by immunohistochemistry (n = 4 each group). Data represent means ± SE. *P < 0.05 (two-tailed paired t-test).