Table 1.
Demographic and clinical features based on SVR12 status.
| Total (n = 494) | No SVR12 (n = 15) | SVR12 (n = 479) | p value | |
|---|---|---|---|---|
| Age in year, mean (SD) | 53.50 (13.07) | 55.47 (15.40) | 53.44 (13.00) | 0.2947 |
| Male, n (%) | 237 (47.98) | 8 (53.33) | 229 (47.81) | 0.6732 |
| Prior treatment experienced | ||||
| Overall, n (%) | 18 (3.64) | 4 (26.67) | 14 (2.92) | <0.0001 |
| Prior IFN-based regimen, n (%) | 13 (2.63) | 2 (13.33) | 11 (2.30) | 0.0554 |
| Cirrhosis, n (%) | 0.0264 | |||
| Compensated | 110 (22.26) | 8 (53.33) | 102 (21.34) | |
| Decompensated | 6 (1.21) | 0 (0.00) | 6 (1.26) | |
| History of HCC, n (%) | 10 (2.02) | 1 (6.67) | 9 (1.88) | 0.2679 |
| HIV/HCV or HBV/HCV co-infection, n (%) | 20 (4.05) | 2 (13.33) | 18 (3.76) | 0.235 |
| Solid organ transplant recipients, n (%) | 10 (2.02) | 0 (0.00) | 10 (2.09) | >0.9999 |
| GT, n (%) | 0.2737 | |||
| GT1 | 355 (71.86) | 9 (60.00) | 346 (72.23) | |
| GT2 | 91 (18.42) | 3 (20.00) | 88 (18.37) | |
| GT3 | 32 (6.46) | 3 (20.00) | 29 (6.05) | |
| GT6 | 7 (1.42) | 0 (0.00) | 7 (1.46) | |
| unknown or mixed | 9 (1.82) | 0 (0.00) | 9 (1.88) | |
| HCV RNA (Log10 IU/ml), mean (SD) | 5.99 (0.96) | 6.20 (0.75) | 5.99 (0.97) | 0.314 |
| Liver stiffness measurement (LSM) (kPa), median (IQR) | 9.00 (9.00) | 13.5 (18) | 6 (8) | 0.3118 |
| ALT (U/L), median (IQR) | 43 (44) | 41.5 (26) | 43 (45) | 0.9603 |
| Bilirubin (μmol/L), median (IQR) | 14 (8) | 14.5 (6) | 14 (8) | 0.3903 |
| Albumin (g/L), mean (SD) | 43.40 (6.12) | 42.50 (5.54) | 43.43 (6.14) | 0.7132 |
| AFP (ng/ml), median (IQR) | 5 (6) | 7 (20) | 5 (6) | 0.3723 |
| eGFR (ml/min/1.73 m2), mean (SD) | 97.17 (24.64) | 104.00 (20.45) | 97.00 (24.73) | 0.588 |
| Platelets (109/L), median (IQR) | 159 (101) | 138 (109) | 159 (100) | 0.4332 |
| Hemoglobin (g/L), mean (SD) | 136.79 (24.14) | 139.4 (24.98) | 136.7 (24.14) | 0.7661 |
Data expressed as mean (standard deviation) or median (Q3–Q1) or sample size and proportion (%). SD, standard deviation; IQR, interquartile range; SVR, sustained virologic response; IFN, interferon; HCC, hepatocellular carcinoma; HIV, human immunodeficiency virus; GT, genotype; HCV, hepatitis C virus; HBV, hepatitis B virus; ALT, alanine aminotransferase; AFP, alpha-fetoprotein; eGFR, estimated glomerular filtration rate.