Table 3.
Factors associated with SVR12.
| Variables | Unadjusted | Adjusted | ||
|---|---|---|---|---|
| Univariate OR (95%CI) | p value | Multivariate OR (95%CI) | p value | |
| Age (years) | 1.012 (0.972,1.054) | 0.5551 | 0.967 (0.912,1.024) | 0.249 |
| Male | 1.248 (0.445,3.495) | 0.6737 | 1.271 (0.276,5.852) | 0.7586 |
| HCV RNA (Log10 IU/ml) | 1.296 (0.672,2.499) | 0.4397 | 1.563 (0.627,3.897) | 0.338 |
| Liver stiffness measurement (LSM) (kPa) | 1.043 (1.006,1.082) | 0.0221 | 1.041 (0.990,1.093) | 0.1156 |
| History of HCC | 3.723 (0.441,31.425) | 0.2272 | <0.001 (<0.001, >999.999) | 0.9805 |
| Bilirubin (μmol/L) | 1.000 (0.962,1.039) | 0.9886 | 0.975 (0.869,1.094) | 0.6676 |
| ALT (U/L) | 0.997 (0.985,1.009) | 0.6293 | 0.975 (0.937,1.014) | 0.1985 |
| AST (U/L) | 1.002 (0.989,1.015) | 0.7618 | 1.006 (0.969,1.046) | 0.7429 |
| AFP (ng/ml) | 1.002 (1.000,1.003) | 0.0303 | 1.001 (0.999,1.004) | 0.3683 |
| Regimens | ||||
| SOF+RBV | Ref | Ref | Ref | Ref |
| SOF+DCV ± RBV | 0.481 (0.058,3.961) | 0.9615 | 0.950 (0.080,11.255) | 0.9673 |
| EBR/GZR | <0.001 (<0.001, >999.999) | 0.9482 | <0.001 (<0.001, >999.999) | 0.9647 |
| OBV/PTV/r/DSV ± RBV | 0.370 (0.109,1.252) | 0.9675 | 0.486 (0.089,2.654) | 0.4046 |
| ASV+DCV | 2.962 (0.569,15.415) | 0.9202 | 6.595 (0.724,60.036) | 0.0941 |
| Platelets (109/L) | 0.997 (0.989,1.004) | 0.4019 | 0.997 (0.985,1.009) | 0.6393 |
SVR, sustained virologic response; OR, odds ratio; CI, confidence intervals; HCV, hepatitis C virus; IFN, interferon; HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, alpha-fetoprotein; SOF, sofosbuvir; RBV, ribavirin; DCV, daclatasvir; EBR/GZR, elbasvir/grazoprevir; OBV/PTV/r/DSV, ombitasvir/paritaprevir/ritonavir and dasabuvir; ASV, asunaprevir.