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. 2020 May 19;11:698. doi: 10.3389/fphar.2020.00698

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Copyright © 2020 Irfan, Kwon, Lee, Shin, Yuk, Kim, Hong, Kim and Rhee

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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U. parvifolia elevates cAMP production and enhances VASP and PKAαβγ phosphorylation. (A) cAMP immunoassay performed for collagen-stimulated washed platelets pre-treated with various U. parvifolia extract concentrations, vehicle, or forskolin. (B) Immunoblotting analysis conducted for the phosphorylation of total VASP, p-VASP^ser157, and PKAαβγ extracted from platelets. Representative immunoblot images and graphs plotted for the data (mean ± SD values) obtained from at least four independent experiments are shown. *p < 0.05 and ***p < 0.001 versus agonist-treated group.