Figure 2.

PCA-DA scores and loading plots. (A) 2D PCA-DA scores of DNA adducts obtained from adductome analysis. Light blue; 1,4-dioxane 0 ppm (control), pink; 1,4-dioxane 20 ppm, yellow; 1,4-dioxane 200 ppm, red; 1,4-dioxane 5,000 ppm. (B) Variable loading plots. Each red spot represents a DNA adduct observed in the DNA adductome analysis. (C) The intensity of each DNA adduct enclosed in a square region was confirmed. The candidate characteristic DNA adducts for 1,4-dioxane exposure are indicated by arrowheads.