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. 2020 May 19;8:280. doi: 10.3389/fcell.2020.00280

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Copyright © 2020 Zhang, Liu, Zhang, Li, Li, Wang, Chand, Guan, Zang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression landscape of HHLA2 in different types of solid tumors. (A) mRNA gene expression of HHLA2 in 22 tumor types was analyzed by using the mRNA-sequencing data from the TCGA database. (B) Representative IHC of HHLA2 expression in 12 types of tumor tissues. Full-sized images were acquired at 10 × and zoomed-in images were originally acquired at 40 ×. (C) HHLA2 protein expression in human cancers detected by immunohistochemistry via tissue microarrays; positive cases were analyzed. (D) The HHLA2 score was evaluated in each sample based on positive staining and intensity. A summary of HHLA2 score in human cancers was listed.