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. 2020 May 19;14:499. doi: 10.3389/fnins.2020.00499

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Copyright © 2020 Mohammed, Bayford and Demosthenous.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulating network used to simulate the effect of DBS on neuronal signals. (A) Basal-ganglia network model. (B) Frequency response for configuration with non-PD having higher amplitude in both bands. (C) Frequency response for a configuration with PD having higher amplitude in both bands. (D) Frequency response for a configuration with non-PD having higher amplitude in band 1, and PD having higher amplitudes in band 2. CV_NPD is the coefficient of variation for non-PD LFP signal and CV_PD is the coefficient of variation for PD LFP signal.