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. 2020 May 19;11:465. doi: 10.3389/fphys.2020.00465

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Copyright © 2020 Mendonca Costa, Anderson, Meijborg, O’Shea, Shattock, Kirchhof, Coronel, Niederer, Pavlovic, Dhanjal and Winter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of altering sodium channel conductance and intracellular conductivity on electrogram morphology in a mouse of a propagating mose ventricular action potential. (A) Simulated bipolar electrograms with decreasing sodium channel conductance (gNa) and intracellular conductivity (σi). Red shading shows the calculated electrogram area. Data are shown for electrode diameters of 0.1 and 1 mm. (B–D) Data showing changing signal amplitude (B), absolute electrogram area (EA), (C), and (D) normalized EA (norm_EA) as a % of gNa and σi (presented data for 0.1 mm electrode diameter).