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. 2020 May 19;11:465. doi: 10.3389/fphys.2020.00465

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Copyright © 2020 Mendonca Costa, Anderson, Meijborg, O’Shea, Shattock, Kirchhof, Coronel, Niederer, Pavlovic, Dhanjal and Winter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of altered sodium channel conductance and intracellular conductivity on electrogram morphology and its relationship with local conduction delay. (A–C) Data showing the impact of altering electrode diameter on the relationship between normalized electrogram area (norm_EA) and local tissue conduction delay with altered sodium channel conductance (gNa)/intracellular conductivity (σ_i) in a computational model of a propagating mouse ventricular action potential. Data are shown for three different electrode diameters. (D–F) The same data for bipolar electrogram amplitude.