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. 2020 May 19;11:465. doi: 10.3389/fphys.2020.00465

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Copyright © 2020 Mendonca Costa, Anderson, Meijborg, O’Shea, Shattock, Kirchhof, Coronel, Niederer, Pavlovic, Dhanjal and Winter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of sodium channel blockade and gap junction inhibition on electrogram morphology in isolated mouse hearts. (A–C) Data showing the effects of increasing concentrations of flecainide on bipolar electrogram amplitude, absolute electrogram area (EA) and normalized EA (norm_EA). (D–F) The same panels but for increasing concentrations of carbenoxolone. (G,H) Correlation between norm_EA and local activation delay (as assessed from the difference in activation time between adjacent electrodes/unipolar electrograms). Difference from 0 μmol/L; *p < 0.05, **p < 0.01, ***p < 0.001. Data are mean ± SEM. Actual replicates are shown in gray. n = 6,7 hearts per group.