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. 2020 May 19;11:615. doi: 10.3389/fphar.2020.00615

Figure 1.

Figure 1

Time line, area stimulated, and sensory stimuli used in this study. (A) Sensory testing at baseline was performed on day 0 (D0), after which participants received a capsaicin patch for 1 h. Thereafter post-treatment sensory testing was conducted at days 1, 3, and 7 (D1, D3, D7) after capsaicin treatment. (B) Testing locations at the volar forearm: C1–C5: capsaicin-treated skin; B1–B4: border skin (1.5 cm away from the border of capsaicin-treated skin), R1–R4 remote skin (3.5 cm away from the border of capsaicin-treated skin). Additionally four locations at the contralateral arm were stimulated. For each type of stimulus, every single location was stimulated three times. (C) Different types of transient thermal stimuli were used to assess capsaicin-induced changes in thermal sensitivity.