Figure 4.

Responding to intermediate-intensity heat stimuli at remote locations of the capsaicin-treated forearm (yellow), close to the border of the capsaicin-treated skin (orange), at the capsaicin-treated skin (red), and at the contralateral forearm (purple). (A) Percentage of non-perceived stimuli in response to intermediate-intensity heat stimuli predominantly activating C-fiber thermonociceptors [C-fiber heat (44°C)]. (B) Intensity ratings. (C) Reaction times. Graphs represent mean ± SEM. The ⁺indicates significant differences at D1–D7 compared to D0 within one location, *indicates significant differences between remote and capsaicin locations, ^#indicates significant difference between border and capsaicin locations, and ^°indicates significant differences between the contralateral locations compared to the capsaicin-treated location (+ ≤ 0.05, ++ ≤ 0.01 and ***/+++/###/°°° ≤ 0.001).