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. 2020 May 19;8:366. doi: 10.3389/fcell.2020.00366

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Copyright © 2020 Yin, Song, Zhao, Liu, Kang, Lee, Kim, Zhang, Shim, Liu, Dong and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Xanthohumol promotes the degradation of KRT18 protein. (A) The mRNA level of KRT18 was examined after treated with xanthohumol for 48 h by RT-QPCR, AGE (agarose gel electrophoresis) results showed the intensity of KRT18 mRNA and β-Actin. (B) RT-QPCR results showed the mRNA level of KRT18 was not changed by xanthohumol treatment. (C) Western blotting results showed xanthohumol treatment decreased the protein level of KRT18. (D) MG132 treatment restored xanthohumol-induced KRT 18 degradation.