TABLE 3.
In vitro synergy testing results of miltefosine in combination with amphotericin B against C. krusei preformed biofilms.
| MIC (μ g/mL) of |
MIC (μ g/mL) of |
||||||||
| ID | AMB | MIL | AMB/MILa | FICIb | ID | AMB | MIL | AMB/MILa | FICIb |
| 3 | 8 | 8 | 2/4 | 0.75 | 37 | 16 | 8 | 2/2 | 0.375 |
| 11 | 8 | 8 | 2/2 | 0.5 | 39 | 16 | 16 | 8/4 | 0.75 |
| 17 | 16 | 8 | 8/2 | 0.75 | 41 | 16 | 8 | 4/4 | 0.75 |
| 21 | 16 | 16 | 8/4 | 0.75 | 42 | 8 | 8 | 4 / 2 | 0.75 |
| 24 | 8 | 8 | 4/2 | 0.75 | 45 | 16 | 8 | 4/2 | 0.5 |
| 25 | 16 | 8 | 2/4 | 0.625 | 47 | 16 | 8 | 2/4 | 0.625 |
| 27 | 8 | 8 | 2/4 | 0.75 | 49 | 8 | 8 | 2/4 | 0.75 |
| 30 | 8 | 8 | 2/4 | 0.75 | 51 | 16 | 8 | 4/4 | 0.75 |
aThe 80% inhibition endpoint was used for this combination. bFICI values in bold indicate synergy. AMB, amphotericin B; MIL, miltefosine; FICI, fractional inhibitory concentration index.