TABLE 4.
Effect of exogenous sorbitol and ergosterol on the MIC (μg/mL) values of miltefosine against clinical C. krusei isolates.
Isolates | Sorbitol |
Ergosterol |
|||
ID | Absence | Presence |
Absence | Presence | |
2 days | 7 days | ||||
3 | 2 | 2 | 2 | 2 | 16 |
17 | 1 | 1 | 1 | 1 | 8 |
25 | 2 | 2 | 2 | 2 | 8 |
36 | 2 | 2 | 2 | 2 | 16 |
43 | 2 | 2 | 2 | 2 | 8 |
52 | 2 | 2 | 2 | 2 | 8 |
ATCC6258 | 2 | 2 | 2 | 2 | 16 |
*CAS | 0.25 | >8 | >8 | – | – |
#AMB | – | – | – | 1 | >16 |
*CAS, caspofungin, positive control for sorbitol assay; #AMB, amphotericin B, positive control for ergosterol assay.