Table 1.
Baseline clinical characteristics of lung cancer patients in SEER database.
| Characteristics | Bone metastasis | Brain metastasis | Liver metastasis | DL metastasis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No (%) | Yes (%) | P | No (%) | Yes (%) | P | No (%) | Yes (%) | P | No (%) | Yes (%) | P | |
| Histological type | ||||||||||||
| Adenocarcinoma | 59,090 (78.5) | 16,141 (21.5) | <0.001 | 63,943 (85.0) | 11,288 (15.0) | <0.001 | 68,647 (91.2) | 6,584 (8.8) | <0.001 | 70,399 (93.6) | 4,832 (6.4) | <0.001 |
| Squamous cell carcinoma | 33,033 (88.8) | 4,146 (11.2) | 35,061 (94.3) | 2,118 (5.7) | 34,874 (93.8) | 2,305 (6.2) | 35,737 (88.0) | 1,442 (12.0) | ||||
| LCLC | 2,322 (82.0) | 510 (18.0) | 2,342 (82.7) | 490 (17.3) | 2,441 (86.2) | 391 (13.8) | 2,601 (91.8) | 231 (8.2) | ||||
| SCLC | 17,427 (76.7) | 5,282 (23.3) | 18.913 (83.3) | 3,796 (16.7) | 15,549 (68.5) | 7,160 (31.5) | 20,308 (89.4) | 2,401 (10.6) | ||||
| NSCLC/NOS | 16,749 (78.7) | 4,541 (21.3) | 17,736 (83.3) | 3,554 (16.7) | 18,341 (86.1) | 2,949 (13.9) | 19,803 (93.0) | 1,487 (7.0) | ||||
| Gender | ||||||||||||
| Male | 66,188 (79.2) | 17,382 (20.8) | <0.001 | 72,491 (86.7) | 11,079 (13.3) | 0.295 | 72,929 (87.3) | 10,641 (12.7) | <0.001 | 77,683 (93.0) | 5,887 (7.0) | <0.001 |
| Female | 62,433 (82.5) | 13,238 (17.5) | 65,504 (86.6) | 10,167 (13.4) | 66,923 (88.4) | 8,748 (11.6) | 71,165 (94.0) | 4,506 (6.0) | ||||
| Age | ||||||||||||
| <50 | 5,129 (74.9) | 1,717 (25.1) | <0.001 | 5,361 (78.3) | 1,485 (21.7) | <0.001 | 5,936 (86.7) | 910 (13.3) | <0.001 | 6,156 (89.9) | 690 (10.1) | <0.001 |
| 51–65 | 39,240 (77.7) | 11,276 (22.3) | 41,365 (81.9) | 9,151 (18.1) | 43,568 (86.2) | 6,948 (13.8) | 46,254 (91.6) | 4,262 (8.4) | ||||
| ≥65 | 84,252 (82.7) | 17,627 (17.3) | 91,269 (89.6) | 10610 (10.4) | 90,348 (88.7) | 11,531 (11.3) | 96,438 (94.7) | 5,441 (5.3) | ||||
| Marital status | ||||||||||||
| Married | 62,526 (79.8) | 15,860 (20.2) | <0.001 | 67,634 (86.3) | 10,752 (13.7) | <0.001 | 68,786 (87.8) | 9,600 (12.2) | 0.625 | 73,147 (93.3) | 5,239 (6.7) | 0.035 |
| Unmarried | 60,049 (81.7) | 13,420 (18.3) | 63,833 (86.9) | 9,636 (13.1) | 64,562 (87.9) | 8,907 (12.1) | 68,772 (93.6) | 4,697 (6.4) | ||||
| Unknown | 6,046 (81.9) | 1,340 (18.1) | 6,528 (88.4) | 858 (11.6) | 6,504 (88.1) | 882 (11.9) | 6,929 (93.8) | 457 (6.2) | ||||
| Race | ||||||||||||
| White | 103,885 (80.9) | 24,502 (19.1) | <0.001 | 111,722 (87.0) | 16,665 (13.0) | <0.001 | 112,357 (87.5) | 16,030 (12.5) | <0.001 | 120,108 (93.6) | 8,279 (6.4) | 0.009 |
| Black | 15,612 (81.5) | 3,555 (18.5) | 16,447 (85.8) | 2,720 (14.2) | 17,055 (89.0) | 2,112 (11.0) | 17,889 (93.3) | 1,278 (6.7) | ||||
| Others | 9,124 (78.1) | 2,563 (21.9) | 9,826 (84.1) | 1,861 (15.9) | 10,440 (89.3) | 1,247 (10.7) | 10,851 (92.8) | 836 (7.2) | ||||
| Grade | ||||||||||||
| I | 7,240 (94.3) | 434 (5.7) | <0.001 | 7,405 (96.5) | 269 (3.5) | <0.001 | 7,521 (98.0) | 153 (2.0) | <0.001 | 7,573 (98.7) | 101 (1.3) | <0.001 |
| II | 23,464 (90.6) | 2,444 (9.4) | 24,237 (93.6) | 1,671 (6.4) | 25,041 (96.7) | 867 (3.3) | 25,312 (97.7) | 596 (2.3) | ||||
| III | 33,521 (83.9) | 6,441 (16.1) | 34,842 (87.2) | 5,120 (12.8) | 36,528 (91.4) | 3,434 (8.6) | 37,754 (94.5) | 2,208 (5.5) | ||||
| IV | 3,901 (80.4) | 951 (19.6) | 4,121 (84.9) | 731 (15.1) | 3,836 (79.1) | 1,016 (20.9) | 4,434 (91.4) | 418 (8.6) | ||||
| Unknown | 60,495 (74.8) | 20,350 (25.2) | 67,390 (83.4) | 13,455 (16.6) | 66,926 (82.8) | 13,919 (17.2) | 73,775 (91.3) | 7,070 (8.7) | ||||
| Size (cm) | ||||||||||||
| <2.0 | 17,612 (89.1) | 2,160 (10.9) | <0.001 | 18,206 (92.1) | 1,566 (7.9) | <0.001 | 18,536 (93.7) | 1,236 (6.3) | <0.001 | 19,025 (96.2) | 747 (3.8) | <0.001 |
| 2.0–4.9 | 51,049 (82.2) | 11,029 (17.8) | 54,351 (87.6) | 7,727 (12.4) | 55,967 (90.2) | 6,111 (9.8) | 58,838 (94.8) | 3,240 (5.2) | ||||
| 5.0–9.9 | 32,257 (79.1) | 8,511 (20.9) | 34,305 (84.1) | 6,463 (15.9) | 35,269 (86.5) | 5,499 (13.5) | 37,835 (92.8) | 2,933 (7.2) | ||||
| ≥10.0 | 3,844 (79.8) | 974 (20.2) | 4,067 (85.4) | 751 (15.6) | 4,123 (85.6) | 695 (14.4) | 4,383 (91.0) | 435 (9.0) | ||||
| Unknown | 23,859 (75.0) | 7,946 (25.0) | 27,066 (85.1) | 4,739 (14.9) | 25,957 (81.6) | 5,848 (18.4) | 28,767 (90.4) | 3,038 (9.6) | ||||
| Regional lymph node invasion | ||||||||||||
| N0 | 53,156 (90.4) | 5,630 (9.6) | <0.001 | 54,430 (92.6) | 4,356 (7.4) | <0.001 | 55,846 (95.0) | 2,940 (5.0) | <0.001 | 57,998 (98.7) | 788 (1.3) | <0.001 |
| N1 | 10,999 (82.5) | 2,337 (17.5) | 11,604 (87.0) | 1,732 (13.0) | 11,952 (89.6) | 1,384 (10.4) | 12,824 (96.2) | 512 (3.8) | ||||
| N2 | 44,427 (75.6) | 14,321 (24.4) | 48,970 (83.4) | 9,778 (16.6) | 48,861 (83.2) | 9,887 (16.8) | 54,392 (92.6) | 4,356 (7.4) | ||||
| N3 | 15,408 (70.4) | 6,479 (29.6) | 17,707 (80.9) | 4,180 (19.1) | 18,009 (82.3) | 3,878 (17.7) | 17,249 (79.6) | 4,458 (20.4) | ||||
| NX | 4,631 (71.4) | 1,853 (28.6) | 5,284 (81.5) | 1,200 (18.5) | 5,184 (80.0) | 1,300 (20.0) | 6,205 (95.7) | 279 (4.3) | ||||
| Surgery | ||||||||||||
| Yes | 32,518 (98.8) | 400 (1.2) | <0.001 | 32,346 (98.3) | 572 (1.7) | <0.001 | 32,760 (99.5) | 158 (0.5) | <0.001 | 32,783 (99.6) | 135 (0.4) | <0.001 |
| No | 96,103 (76.1) | 30,220 (23.9) | 105,649 (83.6) | 20,674 (16.4) | 107,092 (84.8) | 19,231 (15.2) | 116,065 (91.9) | 10,258 (8.1) | ||||
| Chemotherapy | ||||||||||||
| Yes | 58,803 (77.5) | 17,117 (22.5) | <0.001 | 64,268 (84.7) | 11,652 (15.3) | <0.001 | 65,583 (86.4) | 10,337 (13.6) | <0.001 | 69,507 (91.6) | 6,413 (8.4) | <0.001 |
| No | 69,818 (83.8) | 13,503 (16.2) | 73,727 (88.5) | 9,594 (11.5) | 74,269 (89.1) | 9,052 (10.9) | 79,341 (95.2) | 3,980 (4.8) | ||||
| Radiation therapy | ||||||||||||
| Yes | 50,966 (76.8) | 15,387 (23.2) | <0.001 | 50,744 (76.5) | 15,609 (23.5) | <0.001 | 59,939 (90.3) | 6,414 (9.7) | <0.001 | 62,016 (93.5) | 4,337 (6.5) | 0.895 |
| No | 77,655 (83.6) | 15,233 (16.4) | 87,251 (93.9) | 5,637 (6.1) | 79,913 (86.0) | 12,975 (14.0) | 86,832 (93.5) | 6,056 (6.5) | ||||
ΔOthers include American Indian, AK Native, Asian, and Pacific Islander. LCLC, Large-cell lung cancer; SCLC, Small-cell lung cancer; NSCLC, Non-small cell lung cancer.