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Biogenesis of circRNAs. (A) Long flanking introns, inverted repeat elements, and RNA binding proteins are facilitated to back-splicing. (B) Circular intronic RNAs (ciRNAs) can be generated from intronic lariat precursors that escape from debranching. Bss, back-splice site; EIciRNA, exon-intron circRNA; ciRNA, circular intronic RNA.
