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. 2020 May 19;14:103. doi: 10.3389/fncel.2020.00103

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Copyright © 2020 Papalampropoulou-Tsiridou, Labrecque, Godin, De Koninck and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASICs expression in naïve adult mouse DRG. (A–E) Representative confocal images showing the presence of ASIC1a (A), ASIC1b (B), ASIC2a (C), ASIC2b (D), and ASIC3 (E) transcripts in DRG neurons with different neuronal markers, including IB4, CGRP, and NF200. (F) Percentage of the marker positive neurons expressing different ASIC subunits. Arrow heads point to neurons expressing only ASIC1a, ASIC1b, or IB4. Arrows point to ASIC/marker-double positive neurons. The expression pattern of the five ASICs subunits was significantly different among the three neuronal subpopulations (****p < 0.0001, using two-way ANOVA). Scale bar = 50 μm; n = 9–19 DRGs from 3 to 4 naïve mice.