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. 2020 May 19;14:103. doi: 10.3389/fncel.2020.00103

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Copyright © 2020 Papalampropoulou-Tsiridou, Labrecque, Godin, De Koninck and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall expression levels of the different ASIC subunits were not altered after nerve injury. (A) Sciatic nerve cuff model was chosen to induce peripheral nerve injury. Mechanical sensitivity of plantar area of hind paws was measured before and after the surgery. (B) The paw withdrawal threshold of nerve-injured animals, but not sham animals, was significantly decreased after the surgery (N = 14 and 16 animals for the sham and cuff group, respectively; ****p < 0.0001 using two-way ANOVA test, followed by Sidak’s multiple comparisons test). (C) Real time qPCR results comparing the global mRNA levels of ASIC subunits between nerve-injured and sham animals; N = 4 for both sham and cuff groups. Each point represents a merger of L4, L5, and L6 DRGs of 2–3 animals of the same condition. No significant difference was found with two-way ANOVA test.